Activate Nrf2, then optimize: Brussels sprouts
 
Hahaha What can't you do, Nrf2?

Remember The Day Almonds Became Interesting? Namely, "the long series of  unlikely events that must occur in order for the bifidogenic effects of almonds to manifest." Well, it happened again. Or the opposite.

I'm not a huge fan of antioxidant supps for a variety of reasons, including but not limited to ATBC and CARET. There are certainly some exceptions to this, although your body can handle itself quite well under most circumstances.

I am, however, a pretty big fan of periodically doing things like activating #Nrf2, because anti-cancer. Advantage is that if there's nothing going on, Nrf2 is degraded pretty quickly (can't really say the same about antiox supps). If there is something going one, Nrf2 rallies the troops to swiftly restore balance: pathways pathways pathways -> DEAD CANCER CELLS.



IT DOESN'T GET ANY EASIER THAN THIS, FAM


One of the major ways Nrf2 gets it done is by inducing the synthesis of endogenous protective compounds like glutathione. Glutathione synthesis requires sulfury stuff, particularly (if it's available), cysteine. Guess what?

Sulforaphane activates Nrf2 and breaks down to provide cysteine for glutathione synthesis. WEIRD COINCIDENCE, I KNOW RIGHT?

WHAT CAN ANY REMOTELY REASONABLE PERSON CONCLUDE FROM THIS?

...

...

  1. Mother Nature embedded the Nrf2 signaling pathways in us intentionally, because she didn't want us to get cancer.
  2. She cleverly invented a molecule (sulforaphane) which could both activate Nrf2 then be incorporated into one of Nrf2's greatest weapons (glutathione).
  3. She put that molecule all around us in tasty LC plants.
  4. She added a kill-switch to rapidly degrade Nrf2 when the coast is clear.
  5. OR SOMEONE GAVE ME CRAZY PILLS



"Disrupting the Keap1-Nrf2 pathway enhances Nrf2 activity, which has been identified as an important approach for the prevention of different chronic diseases in which oxidative stress and inflammation are present, such as cancer, diabetes, Alzheimer's, and Parkinson's" (Bello and Morales-Gonzalez, 2017)

Role of the Keap1-Nrf2 pathway in cancer (Leinonin et al., 2014)

"Nrf2 can protect cells and tissues from a variety of toxicants and carcinogens by increasing the expression of a number of cytoprotective genes" (Jaramillo and Zhang, 2013)

Curcumin -> Nrf2 -> dead breast cancer cells (Chen et al., 2014)

[drops mic]

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calories proper