Effect of combined use of a low(ish)-carbohydrate, high-protein diet with omega-3 polyunsaturated fatty acid supplementation on glycemic control in newly diagnosed type 2 diabetes: a randomized, double-blind, parallel-controlled trial (Liu et al., 2018)
There were FOUR groups: 1) high-carb, low protein (HCLP, aka CONtrol group); 2) LCHP; 3) HCLP+n3; and 4) LCHP+n3. So, instead of just taking a group of people, putting them on LCHP+n3 and comparing the results to baseline, they actually controlled for the variables independently.
All groups were assign 30% fat and the protein was either 17% or 28%. THIS WAS CONFIRMED with serum urea nitrogen and you know how much I like biomarkers! n3 status of the n3 groups were confirmed with plasma n3's and you know how much I like biomarkers!
Some more details on the study design...
OK, so it wasn't whole foods PaleoTM. That'd be kind of difficult in a blinded study, so the high protein group got a high protein supplement whereas the low protein group got an identical-tasting low protein supplement. Same went for the n3 supps. I think you'd know you were in the n3 group if they advised 4 servings of salmon per week.
In nearly every endpoint, there was step-wise improvements: Control < HCLP+n3 < LCHP < LCHP+n3. In other words, pretty much exactly what you'd think.
Insulin declined in both LC groups, but this wasn't designed to be a weight loss study (there were no differences in fat mass or body weight).
All-in-all a good study.
Take home: swap out some carbs for some seafood a couple times a week. It works whether you're trying to lose weight or not!
That's all for now :-)
Consults are open, contact me if you’re interested: [email protected]
Affiliate links: join Binance and get some cryptoassetsor download Honeyminer and get some Bitcoins for free! And now you can mine Bitcoin from your Chromebook!
Still looking for a pair of hot blue blockers? Carbonshade and TrueDark are offering 15% off with the coupon code LAGAKOS and Spectra479 is offering 15% off HERE. If you have no idea what I’m talking about, read this then this.
If you want the benefits of ‘shrooms but don’t like eating them, Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else.