Physiological insulin resistance: benevolent pseudo-diabetes

The mystery of the ketogenic diet: benevolent pseudo-diabetes (Blagosklonny, 2019

 "studies in rodents have found that the ketogenic diet causes diabetes" 



Narrator: No, they don't. In fact, rodent keto studies are all over the board. 

Sometimes glucose tolerance is up, sometimes it's down, sometimes it depends on what you're actually comparing it to -- is the control group low fat or the notoriously misnamed high fat diet (it should just be called an obesogenic diet imo). 

off topic -- just found these and they're awesome. Check out the digits.

OK, in some studies, keto mice are insulin resistant. Sometimes it correlates with body weight. See all the 'somes' here? You can't make broad statements about rodent keto studies.

And you definitely can't use them to support recommendations for human diabetes/obesity.

this probably isn't even keto's strongest suit anyway...

(referring to some genetic and/or neurological conditions)

Spoiler alert: in some cases, keto mice are heavier than low fat diet but lighter than high fat diet-fed mice. Depending on how you want to spin it, choose the control group wisely.

"Starvation-induced pseudo-diabetes" is a real phenomenon. It even happens to breakfast skippers when they finally have lunch. In lab animals, it can result in glucose spilling into the urine. 

The physiology underlying this is not what I'd call a hotly debated topic, either.

A comparison is made to rapamycin which is known to raise glucose levels, at least in lab animals. But it also extends life in some of them. Thing is, low fasting glucose levels bode well for long-term cognitive health... not a great trade-off, imo

 

That's all for now!

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calories proper




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