Nicotinamide Riboside (NR)

or nicotinamide mononucleotide (NMN)

There is some banter about which is the better NAD+ precursor, but I don't think it really matters. They are interconverted in vivo and cost about the same...

*updated: see below.

NR has been studied in both humans and rodents whereas NMN research is primarily rodents. I'm usually biased toward human studies, but again, I don't think it matters in this #context. 

Why NAD+ ?

Because OMG all of the animal studies! It's like resveratrol all over again...

oh wait...

But seriously, old mice given either NAD+ precursor look like young mice by nearly every measure. NR and NMN have never been directly compared, but both produce equally positive effects in the various rodent models in which they've been tested. Eg, this study on NMN (Mills et al., 2016) or this review article (Connell et al., 2019).

And I'm fairly well-convinced NAD+ levels do decline with age...

Here in skin (Massudi et al., 2012):


and here in brain (Zhu et al., 2015): 

-NAD+ levels decline with age

-providing animals with NAD+ precursors gives tremendous results

-NAD+ precursors effectively increase NAD+ in humans. I'm not sure how much more effectively than nicotinamide; maybe it just takes longer, which would be fine.

-YOU CAN DO THIS AT HOME FOR FREE: exercise is the best way imo. This has been shown in human studies.

-Weight loss or maintenance of a reduced weight (calorie restriction, CR) should support NAD+. I'm not aware of the human studies on this, but I'm inclined to believe it.

-People refer to NR/NMN as exercise- and CR-mimetics (eg, Kitada and Kora, 2013).

-You probably won't 'feel it kicking in,' as that's not really how it works. You may feel better in the long run, but researchers have failed to ask this simple question.

-It probably improves the appearance of your skin &/or prevents photoaging/wrinkles, but I like it for the potential long-term influence on cognitive health (eg, Rennie et al., 2015; Lee and Yang, 2019; Tarantini et al., 2019; Xie et al., 2019).  


-I still don't think either is better than the other

ONE LAST QUESTION -- dose timing. Take NR/NMN when NAD+ levels are at their highest, to increase peak NAD+ levels? This would be effective if levels needed to exceed some critical threshold to be of maximal benefit. Or dose when NAD+ levels are at their lowest, to blunt the trough. Theoretically, assume similar AUC. 

It's essentially the difference between dosing a few hours before your biggest meal or a few hours after. I don't know which scenario would be more optimal.

Anyone gonna try 'em? Let me know in the comments!

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calories proper

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