There's a whole spectrum of Python web frameworks. On one end we have the micro-frameworks like bottle, flask, and do some degree Pyramid. On the other things like Django and even CMSes like Wagtail (built on Django) in the far end.
While this is often positioned as an either / or choice, this week you'll meet Ian Dennis Miller, the creator of Flask-Django. An extension to Flask which brings many of the good things from Django to Flask's simple and small API.