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Chasing Value with Five More Biotech Stocks for the Long-run

Jul 26, 2021

Five more biotech stocks to add to the strategy of invest and forget for a potential X10 return. a reminder of why I am engaging in this binge on biotech stocks after having been focused on AI stocks for the past 5 years.

1. Biotech stocks are an unloved stocks sector whilst tech stocks over valued, even the ultra safe stocks such as the Top 10, so I am reluctant to add at current valuations hence why I hit the SELL button for the first time in many years and reduced my exposure to AI stocks by about 40%.

2. That biotech is a derivative of AI, we'll most sectors will soon become a derivative of AI because it is the PRIMARY tech megatrend of our age that will continue to broaden its reach to encompass all sectors of the economy.

3. That one of my former biotech 12xers got taken over (GW Pharma) that flooded my account with cash early May and so that focused my attention on repopulating my portfolio with 10 more biotech stocks where I expect at least 3 to 10x, with most of the rest expected to survive to varying extent. Though this is the stock market and so there are never any guarantees especially where such smallish cap stocks are concerned. 

4. Our beloved AI stocks have been BID UP to high valuations, yes including Google, so they are not CHEAP, even after a 10% to 15% correction i.e. the likes of Microsoft and Amazon are discounting a lot of future earnings growth! Of course that does not necessarily mean that they are about to fall to what I would consider to be fair value let lone cheap levels as they did during March 2020 because at the end of the day they are GOOD stocks so usually command a healthy premium to invest in unless there is a market panic that marks everything lower regardless.

I had planned to have completed and posted this analysis shortly after my last biotech stocks analysis (Five More Small Cap Bio and Tech Stocks to Invest for 2021 and Beyond!), but focus shifted to crypto's on how to capitalise on the crypto bear market by investing in a select portfolio of crypto's at various buying levels, that and expectation of a correction would lower the price of these biotech stocks, which has happened even if the general market has held steady.


  • Blueprint Medicines - BPMC - $84.5 - Risk 3
  • Cara Therapeutics - CARA - $11.94 - Risk 5
  • Takeda - TAK - $16.86 - Risk 1
  • BioDelivery Sciences International - BDSI - $3.65 - Risk 8
  • Aptorum Group - APM - $2.64 - Risk 10
  • High Risk Stocks Portfolio Buying Levels
  • Netflix - FAANG a Buy, Sell or Hold?
  • Trending towards Hyperinflation!
  • Delta Variant! 
  • Solar CME MULTIPLE Black Swans

DISCLAIMER - Investing in Smallish cap stocks is VERY HIGH RISK. The analysis in this article is a matter of opinion provided for general information purposes only and is not intended as investment advice. Information and analysis derived from sources and utilising methods believed to be reliable, but I cannot accept responsibility for any trading or investing losses that may be incurred as a result of this analysis. Individuals should consult with their personal financial advisors before engaging in any investing or trading activities

Firstly here's a reminder of the small cap bio-tech stocks state of play as per my last analysis of which I now personally hold positions in ALL 4 of the biotech stocks mentioned i.e. ABBV, CRSP, NBX, AVR, all of which are trending in the right direction. Though of course I am focused on many multiples towards 10x many years down the road.


A rating of 1 is the lowest risk and 10 highest risk in terms of something going wrong and the stock effectively crashes and burns into becoming a penny stock or even going bust within the next 5 years! This is based on the sum of all my analysis of each stock and given my risk averse nature then most of the stocks will tend to have a low probability of actually going bust within the next 5 years. Still this rating gives an extra measure of risk vs reward when entertaining potential position sizes.


As is the case with the main AI stocks portfolio I will be listing buying levels which are high probability levels that could be achieved during a correction. What I tend to do is put a price alert at the buying level so if triggered I can decide whether to buy, this means I don't need to waste time monitoring any of my stocks for if they fall I will get an alert, and all I need to do is update the buying levels every so often in response to price action. Of course one can also put in selling level alerts if one is looking to cash out or reduce exposure.

However, for high risk stocks I will be listing 2 buying levels, a near buying level and a more distant buying level. The reason being that I may be more inclined to buy some high risk stocks than others, so if I really want to invest in stock x then I would put the price alert at the near buying level, whilst if I am only interested at much lower prices i.e. as the case with Tesla trades, then I would set the alert to act on the more distant price alert level, of course one can set both price alerts and then make up ones mind at the time they are triggered,

Also I will be include the biotech sector IBB ETF to compare each stocks trend against.

Blueprint Medicines - BPMC - $84.5 - Risk 3

I'll start the ball rolling with a relatively large small cap stock with a market cap of $5 billion trading an a dirt cheap PE of 15 which illustrates the extent to which the biotech sector is unloved! If this was one of Cathy Woods tech stocks that PE would be well north of 100! Blueprint develops medicines for people with cancer and hematological disorders in the US and Europe and it is profitable. Peg ratio is also very low at 0.3, whilst Price to Book is a little high at 4. The company has NO debt and equity of $1.4 billion, so even if it returned to making losses for a few years would not impact much on future prospects. Black Rock and Vanguard each own about 10% of the company as the largest shareholders.

The stock price is volatile and range bound trading between about $110 and $45 though with an upward bias, currently coming off a high of $125 with significant support around $70, though could gyrate all the way down to $45. So we are catching this stock at slightly higher level given it's trend i.e. 1st Buying level would be $70, 2nd buying level would be $53, which given it's volatility should be achievable. A X10 target on $70 would imply $700. It's a case of buying towards the bottom of it's range or at least bellow the midway point and wait for the breakout higher. 

Cara Therapeutics - CARA - $11.94 - Risk 5

Another downtrodden unloved small cap biotech stock with a market cap of $600 million, Cara Therapeutics focused on developing and commercialising chemical entities with a primary focus in pruritus and pain by targeting the opioid receptors. Current PE ratio is 51.2 on earnings of 0.23. Yes the PE is a high, but the PEG ratio is low at 0.5, and as is Price to book at 2.9. As is the case with most of these biotech stocks it's a case of investing and waiting several years for the payoffs to materialise, don't know when the breakthroughs will happen but sometime over the next few years. The company is awash with cash with ZERO debt and has had not debt for the past 5 years which means it has a good chance of having enough time and resources to make it to the breakthroughs. 

The stock is trading near its historic low of $9 to $12, so not much down side which compares against the highs of its range of $27 to $30. The share price is very volatile, in fact I would be tempted to range trade it i.e. put a sell limit at $27 to try and capitalize on the volatility with a view to buying back in towards the bottom of the range again.. It does not track the biotech sector much as is the case with most of the small cap stocks they just do their own thing in response to own news events, a X10 target would be about $120, though I would be tempted to let it run to $200. Meanwhile shares were diluted by 7% over the past year. Largest shareholder is Black rock 15%.

Takeda - TAK - $16.86 - Risk 1

Takeda sounds a bit japanese that's because it is a Japanese corporation and the differences to the rest don't stop there! When we imagine pharma / biotech stocks we think about them usually being founded during the past 20 to 30 years, this stocks been around for over 200 YEARS! We'll at least that means the probability of this stock going to zero is going to be very, very low. Secondly like most of it's pharma brethren it trades on an unloved PE of just 14.8 on a market cap of $52 billion, AND pays a dividend of 4.35% with an average annual growth rate of 13%. Takeda is Japans equivalent of Pfizer or JnJ and like those has dozens of drugs under development but trading on half their valuations whilst selling a lot of it's drugs in the US market, in fact Takeda has just broken ground on a new large manufacturing facility in California a few days ago. Looking into who are the big share holders reveals Cathy Woods ARK fund is numero uno, digging deeper apparently she bought in the range $18 to $20 early in the year. Basically getting to buy a mini Johnson and Johnson at a 25% discount.

The stocks been stuck in trading range of between $21 and $16, so not much downside given it's last close of $16.86. Whilst it's wider longer term range is $28 to $20 which is where the stock has spent most of it's time during the past 20 years. So a price below $20 is cheap, which is obvious given the low PE ratio. Of course upside here appears limited unless it has a major drugs or genomics breakthroughs . Though a 5 year investment could see the stock price double with another 20% to 25% from dividends, so on face value is not a X10er but a stock that my screening threw up and well my risk averse nature prompted me to include given that it has a lot of potential upside with very little if any downside i.e. in a worst case scenario if this turns out to be a mistake i.e. no prospects of running to several multiples than I would just set a limit to exit at say $27 and in the meantime collect the dividends. In this market the bargains are few and far between, and to me this looks like a bargain cheap stock with potential to at least double with a 4.35% dividend yield on top. As for Buying level that would be where it is trading right now, so I will be buying some TAK today.

BioDelivery Sciences International - BDSI - $3.65 - Risk 8

BDSI is another hated small cap ($361mln) biotech stock trading on a sub 15 PE (14.86), with forward PE dropping to 12, focused on developing pain management solutions. The company’s portfolio consists of Belbuca and Symproic (opioid induced constipation). Opioid! Hmm, that may explain the suppressed stock price down from a 2014 high of $18. ROIC is a healthy 36% (31st March), and so is the net margin of 16% with both revenue and earnings trending in the right direction for the past 3 years. Financials appear fine, what am I missing? Okay I see a lot of share dilution over the past 3 years of 5% (2020), 35% and 28%. That's a lot of shares being printed, no wonder the stock price is lower! Also the company has a lot of debt but also a lot more cash $116mln to $75mln (debt). Strong earnings growth vs shares dilution vs high debt vs cash surplus makes this a stock that's unlikely to imminently take off. 

The stock price had been trending higher, even beating the IBB up until the end of 2020, so what happened in January to send the stock price into a tailspin? A lot of litigation both from and against. Something is weird about this stock it should be trading higher, they even bought back about $6 mln of shares earlier this year. For some reason this stock is very hated! Short interest? It must be uncertainty surrounding it's litigation concerning 3 of it's patents. This is a tough stock, it is cheap for litigation reasons if resolved in the companies favour then surely should send the stock price to new highs. Whilst downside risk appears limited to about $3. Strategy here could be to invest for a year then if it is still dead basically going nowhere then look to exit with a $5 limit order for a small profit. As there is a risk one could be stuck in a stock that for whatever reason fails to budge out of a trading a range. Anyway the price is near the lows, so downside risk is limited, with the price trending higher 1st Buy is now at $3.65, 2nd buy is at $3.35. So this stock is a case of invest when cheap and give it a year or so to prove itself, if it fails to perform then get out with a small profit.

Aptorum Group - APM - $2.64 - Risk 10

And lastly, can't get much high risk vs reward than Aptorum - This is probably the smallest small cap bio tech stock I have invested in for over a good decade! With only a market cap of $90 million. The stock trades on a dirt cheap PE of 13. Of course one of the reasons is because it is too small cap for institutions and most investors but conversely the more it grows it's revenues and profits the more investor interest will be generated sending the multiple far higher than where it trades today. Of course as is the case with most of the biotech sector we are waiting for the drug trails to come good, for what it's worth it's PEG ratio is 0.2 and Price to Book of 1.9 are good but how reliable?. Also 60% of the companies stock is owned by 1 person, the founder Mr Chung Yeun Huen. An additional investing risk is shareholder dilution that runs at about 12% per annum.

The stock price has collapsed from a Mid 2019 high of $34 into a trading range of $5 to $2 with the most recent price putting the stock near the bottom end of the range. As can be seen by the comparison against sector ETF IBB, the stock basically does it's own thing as it awaits news, it's basically a binary investment could easily more than X10 form there or go to zero, and either could happen a lot sooner than in 5 years time!. And I am not sure that spike to $14 on the chart was tradable but maybe it could be worth putting a sell limit at $14 to try and catch such one day spikes. Buying levels are where it is trading right now i.e. $2.64.

High Risk Stocks Portfolio Buying Levels

Here is my updated high risk stocks table with the new additions that for the time being complete my high risk stocks analysis / investing binge. I have already bought positions in Aptorum, Cara Therapeutic and BioDelivery Sciences International and and will likely be buying Takeda later today, whilst I will wait for the buying level for Blueprint Medicines to be triggered. The table also includes columns for % change since analysis and percent change since 1st buy trigger. For instance Takeda's buying level is the same as its last close therefore the 1st Buy is the last close. Whilst the 1st Buying level for Blueprint Medicines is $70 so when triggered that will be the 1st buy unless it is moved lower before it is triggered in a future update.

And as always do, do your own research before investing and don' forget I consider ALL of these stocks to be HIGH RISK so my positions sizes are small so that I basically invest and forget / don't think about them because I understand they are going to be volatile as hell!

Netflix - FAANG a Buy, Sell or Hold?

I am often asked to take a look at Netflix as being one of the FAANG stocks. However Netflix the streaming service that has made it into many households during the pandemic including our own has never been on my radar because it is not an AI stock, Nevertheless enough patrons have requested I take a look at it then so I will starting with the fundamental state of the corporation that has seen huge growth during the pandemic though despite this growth in revenues and earnings the stock still trades on a lofty PE of 53.4! Whilst it is the beyond the scope of this analysis to generate a EC ratio, nevertheless the PE of 53.4 IS VERY HIGH!

The key metric where Netflix is is concerned is how fast it's subscriber base is growing for it is that which will generate future revenues and profits growth as new subscribers pay their monthly fees and for that we have this chart generated by Netflix themselves - 

The chart speaks for itself, the pandemic giveth and the pandemic (end of) takeit away. The pandemic party is over for Netflix, their new subscriber additions look set to flat line for 2021. So what's going to drive growth and the price earnings multiples lower if Netflix for a while at least are not likely to get many new subscribers and given the slow pace new additions there is a REAL risk that they start to LOSE subscribers which means much heavier spending on marketing to attract new subscribers so as to prevent subscriber counts from going negative which suggests Netflix is in for a couple of tough years ahead that does not justify that earnings multiple regardless of what the likes of clueless copy writers at are suggesting.

Yeh, fools being the operative word. 

This was one of the must buy stocks during the pandemic crash of 2020, when everything was marked lower regardless of the fact that this and many such as the Amazon were going to prosper hugely from the pandemic and so the Netflix stock price literally doubled from the pandemic low of $290 to trade to $575 within 4 months, since which it has been stuck in a trading range of between $575 and $480, completely failed to participated in the tech sector buying binge of the past 12 months for the obvious reason that the stock then as well as now is OVER VALUED!

Netflix is literally trading on thin air waiting for a stock market correction to burst it's bubble that will send this stock that has gone nowhere for 12 months sharply lower as right now Netflix is NOT a growth stock and unlikely to be one for several years as it's primary source of revenues and profits stagnates. Thus the stock should be trading on a multiple of between 15 and 25 X earnings, not 54, that would put the stock price in the range of between $143 to $238 which is set against last close of $515! So unless the Wuhan bio lab releases the updated virus Covid-21 then the prospects for Netflix stock price does not look so good, It could easily fall back into the $400 to $250 trading range. That's not to say it does not have good long-term prospects. it's just that I can't see how it can be higher than where it is today in say 3 or maybe even 4 years years time given the competition from the likes of Amazon Prime and Disney both of whom have deep pockets so can undercut Netflix. Nope Netflix is NOT a good stock to be invested in right now, the stock could easily halve in price and still not be a good buy! In fact if one really want to be invested in a streaming service then one would be infinitely better off investing in say Amazon or Disney than Netflix! Whilst I will continue to ignore this FAANG as not being relevant to my portfolio. So the answer to the question is that Netflix is a SELL.

Trending towards Hyperinflation!

We all know that the governments operate a ponzi scheme, one of printing debt that they sell to the banking crime syndicate that in turn sells to the central bank for printed money who then go back to buy more debt from the government.

where the objective of this ponzi scheme is to keep inflating the value of the currency for instance the US dollar at an approx rate of 2% so as to foster the illusion of prosperity i.e. rising wages and asset prices whilst at the same time the value of debt erodes, as well as the governments tax take increases, a perfect perpetual ponzi system?

Well there are untended consequences and those are the indexed to inflation obligations of the government , i.e. US Social security payments are about to jump by 6.1% due to the surge in CPI, let alone the massively ballooning obligations that are many times GDP quietly ticking away in the background that are INDEXED to inflation, hence why the risk of hyperinflation is REAL! The higher the inflation rate the more the future obligations of the central government INFLATE, all this whilst it becomes successively harder to generate growth with printed money.

How can all of this not end in hyperinflation or at least very high inflation?

Delta Variant! 

Our household got Hit 1st of July! luckily double vaccinations appear to have WORKED, and the household appears to have made it through with little immediate impact, though will have to wait and see what the long-term consequences are. So looking at UK data the delta variant impact on those fully vaccinated is probably going to be on par with that of the flu.

Against this we had 120 scientists writing public warning letters against opening up the UK , whist the government has decided to ignore the scientist drama queens and go ahead the full reopening of UK on the 19th of July a science experiment for the world to watch to see what happens, Where our own recent experience suggests if one is fully vaccinated then the impact of the Delta variant is not going to that different than that which humans were already exposed to prior to covid. i.e, yes the elderly and frail are at far higher risk, but the rest of the population should not worry much about it as long as they are double jabbed.

Though then we have this garbage called Track and Trace pinging everyone left right and centre, forcing over 600,000 workers to self isolate resulting in shortages of some goods in the super markets though nowhere near to the extent of the March 2020 panic buying empty shelves. 


Mainstream media (Washington Post) has blasted holes into the WHO's CCP sponsored propaganda reports into the origins of the virus, prompting the WHO to issue statements that the report is being revised in recognition of 'untended' errors such as that the Wet Market in Hannan district was NOT the origins of the virus as there were cases earlier than 9th December, and that the origins are likely across the Yangtze river in Jiangxia province which is where the Wuhan Institute of Virology is festering it's cocktail of bat viruses.

So slowly, very slowly the trend is inexorably towards the fact that it is a high probability that the Wuhan Lab IS the origins of the virus which has been my consistent view for the duration of the pandemic. Nevertheless the WHO cannot be trusted and remain in the pockets of the CCP.

Solar CME MULTIPLE Black Swans

Having converted my analysis of 25th November 2020 into a video that I shared with patrons in my last analysis.

However, back in November 2020 I imagined the Sun would send our way perhaps 1 major CME, instead the sun is literally exploding with solar flairs and CME's all month luckily so far the most violent have been on the far side of the sun, so we were safe, or should have been but still got barraged with high energy particles such as between Tuesday and last Saturday as CME's to some extent managed to wrap around and fly our way hitting the atmosphere with high energy particles during July and what else have we seen during July? Widespread FIRES and FLOODS, surely they are linked? I.e. a destabilised climate being hit by a barrage of high energy particles creating even more chaotic extreme weather than what one expect from climate change.

What this suggests we are in for one hell of a ride over the next 5 years! I think we are going to be looking back on the Pandemic of 2020 as the good old days before the Sun started exploding every other week sending a series of flairs CME's in our direction. By the time the suns done this could end up costing several multiples of the cost of the Pandemic so continue to expect exponential money printing QE4Ever.

Definitely time to start implementing rather than planning what to do, where now one needs to factor in climate consequences of fires and floods perhaps fell those trees growing nearby or ensure drainage is clear, and if you live in a valley or near a river then well you better consider moving as I last warned some 6 years ago when considering buying a house ensure it is at least 10 metres above the valley floor.

Dec 2015 - UK Climate Change Floods House Prices Crash Could Hit 20% of Properties  

So again as a general rule prospective home buyers should not contemplate buying properties that are less than 10 metres above the height of any nearby river, water way or valley floor which puts virtually all riverside and flood plain properties out of contention so as to mitigate both the risks of actual flooding and negative effects on house prices.

A risk that is now starting to make itself manifest across the world where for the UK it is only a matter of time, probably measured in the months rather than years.

I will next probably take a look at the UK housing market (including a brief update on the state of the US housing market) or a multi month stock market trend forecast.

Your Delta variant recovering analyst.

Nadeem Walayat

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Disclaimer: The above is a matter of opinion provided for general information purposes only and is not intended as investment advice. Information and analysis above are derived from sources and utilising methods believed to be reliable, but we cannot accept responsibility for any trading losses you may incur as a result of this analysis. Individuals should consult with their personal financial advisors before engaging in any trading activities.

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