Episode 62 - David Krantz (Cannabis Nutrigenomics)
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David Krantz is a personal nutrition and genetics coach, sound therapy technician, and electronic music producer based in Asheville, NC.  


This week we chat about genetics – specifically how different gene variations in people affect the way we experience cannabis. We’re coming up on a revolution in biotech and agriculture that will soon make it a possibility to grow gene-tailored strains of cannabis to suit YOUR DNA specifically…until then, though, here is your primer on how to dance with Mary Jane in ways that work WITH, not AGAINST, you.

(David is a repeat guest from Future Fossils Episode 0010, when he chatted with us about the future of electronic music, plant intelligence, and tripping with cats and modular synthesizers. Be sure to check that one out also!)

We Discuss:

• CYP2C9 - a liver enzyme that breaks down THC - and how the amount your body produces will determine how high you get from edibles, your ability to pass a drug screening, etc.

• How learning about our genetic differences helps us develop tolerance and acceptance of each other’s very different needs and bodies

• COMT, a gene responsible for dopamine breakdown, and how which variant of this gene you possess determines cannabis-induced memory loss and alteration of time perception

• ATK1, a gene whose variants determine how “psychotomimetic” (ie, trippy) your response to cannabis will be, and whether or not it will exacerbate schizophrenic symptoms

• How it is, and isn’t, helpful for the law to regard cannabis primarily as a medicine

• APOE, a gene that heavily influences Alzheimer’s Disease, not in isolation but depending on whether or not you eat a lot of saturated fats or exercise

• How we must revolutionize education and accreditation in an age of digital learning, so that we can deploy as much healing intelligence as possible

• Single Nucleotide Polymorphisms, or SNPs, and how these one-letter changes in a gene can make a huge difference

• David’s critique of cannabis studies that DON’T break down research subject populations down into genetic subgroups, and reveal the researchers’ biases

• The need for “cultural interoperability” in our discussions about cannabis research, “across the aisle” between scientists for and against its legalization

• AND Coffee and Chaga mushrooms and more – enacting complex mutually supportive benefits

• Which gene tests David likes best, and best practices for privacy with your genetic data

• The future of genomic science’s influence on cannabis horticulture and use


“There are probably some people that shouldn’t smoke weed.”

“I feel very qualified to help the people that I’m helping, and having the red tape of, ‘You have to be a medical professional or you can’t talk about this stuff at all,’ doesn’t make sense for where we’re going – because I can listen to 2000 hours of podcasts, like I did when I was working at Moog, and feel like I’ve really upped my understanding of some things. Maybe that can help other people besides myself.”

“I’ve become increasingly self-aware of the way I feel about people who disagree with me…”

“There’s no such thing as the perfect human diet.”

Related Links:

Kerri Welch on dopamine and time perception