Real Madrid vs Manchester United
 
Real Madrid 221 * 2..6 - 1000 = -425

Draw 315 * 3.6 - 1 000= 134

Manchester United  320 *4.2 - 1000 = 344

But goals are: 

Real Madrid 2-3

Manchester United 1-2

So it is highly unlikely that Manchester United can win. At best they can draw 2-2.

Conclusion: although we could bet on a draw if we could to stomach losing 2 out of 3, there is limited profit and we don't stomach that. So no bet.