True Blood is supposed to get its oomph from the tension between vampires and normal non fangy non vampire people. That's the usual binary in the vampire serial drama. You've got the vampire slayer, and then you have the vampires; you've got the Bella and then you've got the Edward. The division can mean various things—good and evil, straight and gay, normal and special, persecutors and persecuted, whatever and whatever. But the basic metaphor is the basic metaphor.
But in True Blood, the real binary isn't human/vampire. The real binary is between the fairly standard naturalist Hollywood acting styles of virtually the whole cast, and the weird, campy, mannerist slow-mo performances of Anna Paquin as Sookie and Stephen Moyer as Bill.
Paquin's performance, in particular, is...off. Sookie is supposed to be telepathic and a little weird, but there's more to it than that. When she goes to the vampire bar, Fangoria, her responses are chalkboard fingernail off; she effusively thanks the vampires for looking at pictures of dead girls, and is bubbly and chipper and aw shucks; it's like she stepped out of the Brady Bunch. Her interactions with Bill also seem like they wandered into a standard serial drama from a David Lynch film; whenever he walks into the bar where she works, she orients on him and just about leaps on him. Bill, for his part, speaks and acts in slow motion. When Sookie is being set upon by vampires, he just sits there, waiting till the last minute to intervene, for not apparent earthly reason except that the director has told him to perform as if he's swimming through sludge.
It's not a bad thing for the protagonists to feel like they're wandering through a different script. It actually works quite well thematically; Sookie and Bill's romance is weird and intense, and disturbs both humans and vampires; it makes sense to have it set apart stylistically. It's just very unusual to see a fairly standard television drama experiment with different acting styles in this way. It's hard to think of a critically acclaimed television show that's tried it; shows like Westworld or Sherlock or Stranger Things work for realism, at least in performance; they're quality because they acting is believable, whatever that means.
To embrace camp as a contrasting mode within a show is a statement. I doubt True Blood will do anything particular with it,but still. It's got my interest enough that I'll probably watch at least a couple more.